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生物磁受体蛋白MagR/IscA研究进展

Research progress of biomagnetic receptor protein MagR/IscA

摘要:铁硫簇蛋白是一类重要的线粒体功能蛋白,在细胞能量代谢、电子传递、底物结合与激活、铁/硫存储、酶促反应、基因表达调控等诸多过程中均发挥了关键作用. 一旦铁硫簇组装及转运过程发生障碍,必将严重影响细胞内铁的稳态及铁硫蛋白的功能. 其中,分子量约 11-kDa 的 IscA,是铁硫蛋白亚家族 hesB 之一的高保守性成员,能结合铁离子及[2Fe-2S]簇,从而参与铁硫簇蛋白的合成,因此在铁硫簇组装蛋白系统中具有重要的作用. 更值得关注的是,2015 年谢灿和张生家各自研究组分别发现了 IscA1 具有独特的磁感应(magnetic sensor,MagS)与磁受体(magnetic receptor,MagR)功能. 尤为重要的是,通过外磁场刺激相关磁基因表达,能够调控神经活动及行为定位. 鉴于磁受体的独特功能并结合相关技术,遂将其统称为磁遗传学(磁基因学). 本文简要介绍 IscA 蛋白的始初发现与鉴定历程、进化保守性及其独特的生理生物学功能,并凝练出磁遗传假说机制调控模型.

英文摘要:Iron-sulfur cluster proteins are a class of important mitochondrial functional proteins that play key roles in cellular energy metabolism, electron transport, substrate binding and activation, iron/sulfur storage, enzymatic reactions, and regulation of gene expression. Obstruction in the assembly and transport of iron-sulfur clusters will seriously affect the homeostasis of intracellular iron and the function of iron-sulfur proteins. Among them, IscA with a molecular weight of about 11-kDa is a highly conserved member of the iron-sulfur protein subfamily hesB. It can bind iron ions and [2Fe-2S] clusters, thereby participating in the synthesis of iron-sulfur cluster proteins, so it plays an important role in the iron-sulfur cluster assembly protein system. More noteworthy is that in 2015, Xie Can and Zhang Shengjia respectively The research group found that IscA1 has unique magnetic sensor (MagS) and magnetic receptor (MagR) functions. More importantly, it can regulate neural activity and behavioral localization by stimulating the expression of related magnetic genes through an external magnetic field. In view of the unique functions of magnetic receptors combined with related technologies, they are collectively referred to as magnetogenetics (magnetic genetics). This article briefly introduces the initial discovery and identification process of IscA protein, evolutionary conservation and its unique physiological and biological functions. , and condensed the mechanism regulation model of the magnetic genetic hypothesis.

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[V2] 2016-06-16 14:21:45 chinaXiv:201606.00145V2 下载全文
[V1] 2016-06-15 13:37:55 chinaXiv:201606.00145v1 查看此版本 下载全文
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